Preheat broiler or grill.
Place a large pot of water over high heat to boil the orzo. Salt the boiling water and cook the pasta to al dente according to package directions. Drain the cooked pasta and reserve.
While the pasta is cooking, in a large mixing bowl whisk together 3 tablespoons EVOO with the oregano, onion powder, garlic powder, some salt and pepper. Toss the lamb cubes in the mixture to coat. Thread the lamb onto metal skewers (wooden skewers are ok, too, just soak them in water for 20 minutes prior to use). Broil or grill the lamb until seared and cooked to medium, about 2-3 minutes per side.