Preheat a cast-iron skillet over medium-high heat.
In a large mixing bowl, mix together turkey, cumin, coriander, oregano, garlic, jalapeño, salt and pepper. Form the meat into 4 even-size burger patties.
Add olive oil to the pan and cook the burgers on one side until cooked halfway through and browned, about 3-4 minutes. Flip burgers and cook for an additional 3 minutes, or until completely cooked through.
While burgers are cooking, make your guacamole: In a medium mixing bowl, mix together the red onion, lime juice and salt. Let sit for 10-15 minutes as the salt draws the liquid out of the onions. Mix in avocado, cilantro, and season with pepper.
To build burgers, place a cooked turkey patty on a bun bottom, top with lettuce, tomato and guacamole. Set bun tops in place and serve with a side salad of chopped Romaine lettuce and chopped red and yellow peppers, dressed with favorite salad dressing.
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